Role of dopamine transporter imaging in investigation of parkinsonian syndromes in routine clinical practice
Identifieur interne : 003F53 ( Main/Exploration ); précédent : 003F52; suivant : 003F54Role of dopamine transporter imaging in investigation of parkinsonian syndromes in routine clinical practice
Auteurs : Werner Poewe [Autriche] ; Christoph Scherfler [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-10.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Biological transport, Brain (radionuclide imaging), Corpus Striatum (radionuclide imaging), Diagnosis, Differential, Differential diagnostic, Dopamine, Dopamine Plasma Membrane Transport Proteins, Human, Humans, Indication, Membrane Glycoproteins, Membrane Transport Proteins (analysis), Nerve Tissue Proteins, Neural Pathways (radionuclide imaging), Neurodegenerative Diseases (radionuclide imaging), PET, Parkinson Disease (radionuclide imaging), Parkinsonian Disorders (radionuclide imaging), Parkinsonism, SPECT, Sensitivity and Specificity, Single photon emission tomography, Substantia Nigra (radionuclide imaging), Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon, differential diagnosis, dopamine transporter, parkinsonian disorders.
- MESH :
- chemical , analysis : Membrane Transport Proteins.
- chemical : Dopamine Plasma Membrane Transport Proteins, Membrane Glycoproteins, Nerve Tissue Proteins.
- radionuclide imaging : Brain, Corpus Striatum, Neural Pathways, Neurodegenerative Diseases, Parkinson Disease, Parkinsonian Disorders, Substantia Nigra.
- Diagnosis, Differential, Humans, Sensitivity and Specificity, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon.
Abstract
We discuss the potential role of dopamine transporter (DAT) imaging by single photon emission computed tomography (SPECT) as a biological marker for differentiating among parkinsonian disorders in routine clinical practice, and the implication for disease progression assessment is considered. Although clinical criteria enable accurate and reliable diagnosis of fully developed Parkinson's disease, there are several areas of diagnostic uncertainty relating to atypical parkinsonian disorders, isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug‐induced and psychogenetic parkinsonism. DAT‐SPECT facilitates differential diagnosis of the different parkinsonian syndromes that cannot be reliably separated on clinical grounds and it can thus provide valuable diagnostic information in early disease. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10573
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-10">2003-10</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">S7</biblScope><biblScope unit="supplement">7</biblScope><biblScope unit="page" from="S16">S16</biblScope><biblScope unit="page" to="S21">S21</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B8A987538140B3E030522A74B2A3FF47B90B223F</idno><idno type="DOI">10.1002/mds.10573</idno><idno type="ArticleID">MDS10573</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological transport</term><term>Brain (radionuclide imaging)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Diagnosis, Differential</term><term>Differential diagnostic</term><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Human</term><term>Humans</term><term>Indication</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins (analysis)</term><term>Nerve Tissue Proteins</term><term>Neural Pathways (radionuclide imaging)</term><term>Neurodegenerative Diseases (radionuclide imaging)</term><term>PET</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinsonian Disorders (radionuclide imaging)</term><term>Parkinsonism</term><term>SPECT</term><term>Sensitivity and Specificity</term><term>Single photon emission tomography</term><term>Substantia Nigra (radionuclide imaging)</term><term>Tomography, Emission-Computed</term><term>Tomography, Emission-Computed, Single-Photon</term><term>differential diagnosis</term><term>dopamine transporter</term><term>parkinsonian disorders</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Membrane Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Membrane Glycoproteins</term><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Corpus Striatum</term><term>Neural Pathways</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term><term>Parkinsonian Disorders</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Diagnosis, Differential</term><term>Humans</term><term>Sensitivity and Specificity</term><term>Tomography, Emission-Computed</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Diagnostic différentiel</term><term>Dopamine</term><term>Homme</term><term>Indication</term><term>Parkinsonisme</term><term>Tomoscintigraphie émission monophotonique</term><term>Transport biologique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We discuss the potential role of dopamine transporter (DAT) imaging by single photon emission computed tomography (SPECT) as a biological marker for differentiating among parkinsonian disorders in routine clinical practice, and the implication for disease progression assessment is considered. Although clinical criteria enable accurate and reliable diagnosis of fully developed Parkinson's disease, there are several areas of diagnostic uncertainty relating to atypical parkinsonian disorders, isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug‐induced and psychogenetic parkinsonism. DAT‐SPECT facilitates differential diagnosis of the different parkinsonian syndromes that cannot be reliably separated on clinical grounds and it can thus provide valuable diagnostic information in early disease. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><region name="Tyrol (Land)"><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name></region><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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